Alfonso Iorio   MD (Perugia), PhD, FRCP(C)

Alfonso Iorio

MD (Perugia), PhD, FRCP(C)

Dr Iorio is Professor of Medicine and Health Research Methods, Evidence, and Impact at McMaster University. He is Chief of the Health Information Research Unit and of the Hamilton-Niagara Hemophilia Program.

Research interests

The Health Information Research Unit (HiRU), founded by Brian Haynes, is a knowledge refinery, which main activity is maintain McMaster Premium LiteratUre Service (McMaster PLUS), a second-order peer review database of methodologically sound, clinically relevant and newsworthy peer reviewed publications. McPLUS is used for many scopes, among which providing papers for abstraction in the American College of Physician Journal Club monthly issue of Annals of Internal Medicine, and providing discipline specific news feeds via the BMJ sponsored Evidence Updates service.  The HiRU has created the Clinical Query filters available on the PubMed search engine. HiRU is open to consider any form of collaboration with any commercial, academic or non-for organization aiming at disseminating high quality evidence. For further details on the HiRU’s knowledge translation research program see:

The clinical research program is centered on the application of information technology to the optimization of the clinical management of rare bleeding disorders. The McMaster Hemophilia Research Program, based and partly supported by the Michael de Groote School of Medicine, runs a worldwide epidemiology and pharmacoepidemiology research program based on the following infrastructure: a) the Canadian Bleeding Disorder Registry (CBDR), supporting clinical activities of all bleeding disorder centers in Canada and feeding a central anonymized data repository; b) the Canadian Hemophilia Surveillance System (CHESS), providing real time detection of treatment adverse effects, including the development of inhbitors to factor VIII concentrates (the project is harmonized with the European Haemophilia Surveillance System, EUHASS); c) the Web-available Population Pharmacokinetic Service (WAPPS) and research network, covering 20 countries and over 40 centers, providing easy availability of producing PopPK estimates at the point of care for all available factor concentrates; d) the Patient Reported Outcome, Burden and Experiences (PROBE), a newly developed multilingual assessment tool and research network aiming at generating robust comparative effectiveness data. For furher detailas see: 


Lecturer, Health Research Methodology Course #721 "Introduction to Health Research Methodology” Teaching unit: “Outcome and Measurements”

Lecturer, Health Research Methodology Course #743 "Systematic Reviews” Teaching unit: “Data extraction”

Course coordinator and lecturer, Health Research Methodology Course #777 "Diagnosis and Prognosis” 

Other scholarly activities

Dr Iorio is an Associate Editor of the Cystic Fibrosis and Genetic Disorders Review Group of the Cochrane Collaboration, and a member of the editorial board of BMC Diagnosis and Prognosis, Haemophilia, and Journal and Thrombosis and Haemostasis.

He is Chair of the Data and Demographics Committee of the World Federation of Haemophilia (WFH), member of the GRADE working group, Member of the Guideline Oversight Committee of the American Society of Hematology and of the Guideline Committee of the American College of Physician.

Full publication list:  Click

Click here to find Dr Iorio's Faculty listing.