Alfonso Iorio


Dr. Alfonso Iorio is Professor and Chair, Department of Health Research Methods, Evidence, and Impact, and Chief of the Health Information Research Unit at McMaster University and Director of the Hamilton-Niagara Hemophilia Program. He is a member of the GRADE working group, with specific interest in prognostic studies and rare diseases. He is a member of the Prognosis Method Group of the Cochrane Collaboration, Past Chair of the Data and Demographics Committee of the World Federation of Hemophilia and co-chair of the World Bleeding Disorders Registry. He is member of COVID-END and co-chair of the Context, Evidence and Behaviour pillar of Global Nexus.

Areas of Research Interest

Dr. Iorio is interested in literature search methods to reduce the signal to noise ratio for retrieving clinically ready evidence, including machine learning techniques. His research units provides support in implementing and running literature surveillance systems, from the support of living systematic reviews, to maintaining large collections of clinical recommendations, to automated surveillance of evidence products on website and public databases.


Dr. Iorio obtained his Medicine degree (1991) residency in Clinical Chemistry and Biochemistry (1996) and Internal Medicine (2006) at the University of Perugia, a Master of Science in Clinical Pharmacology and toxicology at the University of Bologna (1998) and a PhD in Medical Communication at the University of Perugia (2015). He is a FRCPC as a general internist since 2012.


Dr Iorio has been inducted in the Canadian Academy of Sciences in 2021.

Current Research Projects

  • Deep learning algorithms to identity clinically ready evidence in Medline
  • Living systematic review of vaccine effectiveness for COVID19 variants of concerns
  • Intervention to improve adherence to medications (SR)
  • Developing GRADE guidance for prognostic modelling studies
  • Assessing the value of population PK based individualized treatment for hemophilia patients
  • Phase III clinical trials of gene therapy in hemophilia
  • Von Willebrand Factor aptamers to modulate factor VIII half-life
  • Phase III clinical trial of VonWillebrand decoupled factor VIII

Educational and Mentorship Activities

  • Trainee supervision

Trainee Supervision

  • Dr Iorio is considering supervision of PhD students for the Health Research Methodology Program at McMaster University and postdoctoral fellows.