Gordon Guyatt


Dr. Gordon Guyatt is a Distinguished Professor in the Department of Health Research Methods, Evidence, and Impact, McMaster University and one of the founders of Evidence-Based Medicine. He has played a key role in over 40 major clinical studies (including both large-scale observational and randomized trials) and has extensive expertise in research methodology. As co-founder and co-chair of the GRADE working group he has been intimately involved in the development and evolution of the GRADE approach. He is a co-founder and Chief Scientific Officer of the Making GRADE the Irresistible Choice (MAGIC) Evidence Ecosystem Foundation which has partnered with BMJ to produce BMJ Rapid Recommendations and with WHO to produce the WHO COVID-19 guidelines for drugs and immunological interventions.

Areas of Research Interest

Dr. Guyatt is interested in methods for development of evidence synthesis and guideline development, measurement of patient reported outcomes, randomized trial methodology, and patient values and preferences


Dr. Guyatt obtained his BA at the University of Toronto (1974), his medical degree at McMaster University (1977), his residency training at the University of Toronto and McMaster University with his FRCP as a general internist in 1981, and a Master of Science in Design, Management, and Evaluation (currently known as the Health Research Methodology program) at McMaster University (1983).


Distinguished University Professor (McMaster, 2010);
Officer of the Order of Canada (2011);
CIHR Researcher of the Year award (2013);
Membership in the Canadian Medical Hall of Fame (2016);

Current Research Projects

  • Methodology of Network Meta-analysis
  • Developing GRADE guidance for Clinical Prediction and Diagnostic Decision Models
  • Living Network Meta-analysis in COVID-19 treatment
  • Guidelines for COVID-19 treatment with the World Health Organization
  • Developing a novel risk of bias instrument for randomized trials
  • Advancing the methodology of minimal important differences in patient-reported outcomes
  • Network meta-analyses in community and hospital acquired pneumonia
  • Values and preferences in patients with small renal masses
  • Randomized trials in peri-operative medicine

Educational and Mentorship Activities

  • From 1990 to 1997, Guyatt directed the internal medicine residency program at McMaster University. Dr Guyatt had led the McMaster Evidence-based Health Care Workshop for over 20 years, and is active in undergraduate and post-graduate education as well as leading EBM workshops around the world.

Trainee Supervision

  • Dr Guyatt is considering supervision of PhD students for the Health Research Methodology Program at McMaster University, postdoctoral fellows, and visiting researchers on a case by case basis.